Lipsey J R, Robinson R G, Pearlson G D, Rao K, Price T R
Lancet. 1984 Feb 11;1(8372):297-300. doi: 10.1016/s0140-6736(84)90356-8.
The efficacy of nortriptyline in the treatment of post-stroke depression was assessed by a double-blind study in thirty-four patients. Half of the patients had major depression. There was a significantly greater improvement in depression in patients treated with nortriptyline than in a similar group of placebo-treated patients. Depression was measured by the Hamilton depression scale, Zung depression scale, present state examination, and an overall depression scale. Successfully treated patients had serum nortriptyline levels in the therapeutic range. Post-stroke depressions are common, severe, and longstanding, and the demonstrated efficacy of nortriptyline provides an important addition to the treatments available for stroke patients.
通过一项针对34名患者的双盲研究评估了去甲替林治疗中风后抑郁症的疗效。一半患者患有重度抑郁症。接受去甲替林治疗的患者的抑郁症状改善程度明显大于接受安慰剂治疗的类似患者组。通过汉密尔顿抑郁量表、zung抑郁量表、现状检查和总体抑郁量表来衡量抑郁程度。成功治疗的患者血清去甲替林水平在治疗范围内。中风后抑郁症常见、严重且持续时间长，去甲替林已证实的疗效为中风患者的现有治疗方法增添了重要内容。
