Dawson R
Neuropharmacology. 1983 Dec;22(12A):1417-9. doi: 10.1016/0028-3908(83)90235-6.
Acute administration of excitatory amino acids alters the release of anterior pituitary hormones. The neurochemical effects of monosodium glutamate (MSG) administration to adult mice were examined 30 minutes and 60 days after an acute injection (4 mg/g). The permanent effects of an acute injection of MSG were limited to a slight loss of neurons in the ventral arcuate nucleus and a 21% reduction in hypothalamic 5-HIAA levels. Thirty minutes after MSG administration hypothalamic DA and DOPAC levels were increased 27% and 25%, respectively and MOPEG levels were increased 75% in the hypothalamus and 34% in the remaining whole brain. These findings show that the acute administration of MSG results in alterations in hypothalamic monoamine metabolism which may be related to the neuroendocrine consequences of excitatory amino acid administration.
急性给予兴奋性氨基酸会改变垂体前叶激素的释放。在成年小鼠急性注射（4毫克/克）味精（MSG）后30分钟和60天，检测了其神经化学效应。急性注射味精的长期效应仅限于腹内侧弓状核中神经元略有损失，以及下丘脑5-羟吲哚乙酸（5-HIAA）水平降低21%。给予味精30分钟后，下丘脑多巴胺（DA）和3,4-二羟基苯乙酸（DOPAC）水平分别升高27%和25%，3-甲氧基酪胺（MOPEG）水平在下丘脑升高75%，在其余全脑中升高34%。这些发现表明，急性给予味精会导致下丘脑单胺代谢改变，这可能与给予兴奋性氨基酸的神经内分泌后果有关。
