白细胞功能异常男孩中缺乏单克隆抗体定义的蛋白质复合物。
Absence of monoclonal-antibody-defined protein complex in boy with abnormal leucocyte function.
作者信息
Beatty P G, Ochs H D, Harlan J M, Price T H, Rosen H, Taylor R F, Hansen J A, Klebanoff S J
出版信息
Lancet. 1984 Mar 10;1(8376):535-7. doi: 10.1016/s0140-6736(84)90933-4.
An 8-year-old boy with severe recurrent bacterial infections was found to lack the cell-surface multimeric polypeptide complex defined by murine monoclonal antibody 60.3. This complex is expressed on the surface of all normal polymorphonuclear leucocytes (PMN), monocytes, and lymphocytes. Incubation of normal lymphocytes or PMN with antibody 60.3 produced functional abnormalities comparable with those observed in the patient's cells, suggesting that the polypeptide complex plays a significant part in several membrane-dependent leucocyte functions.
一名患有严重复发性细菌感染的8岁男孩被发现缺乏由鼠单克隆抗体60.3所定义的细胞表面多聚体多肽复合物。这种复合物在所有正常的多形核白细胞（PMN）、单核细胞和淋巴细胞表面均有表达。用抗体60.3孵育正常淋巴细胞或PMN会产生与在患者细胞中观察到的功能异常相似的情况，这表明该多肽复合物在几种依赖膜的白细胞功能中起重要作用。
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