Day J L, Metcalfe J, Simpson N, Lowenthal L
Am J Med. 1984 Feb 27;76(2A):94-6. doi: 10.1016/0002-9343(84)90963-x.
The effects on plasma lipids of beta-blocking antihypertensive agents with differing degrees of selectivity and intrinsic sympathomimetic activity were studied. The interrelationship between changes in lipid factors, lipoprotein lipase function, the degree of response, and pretreatment characteristics were examined. Beta-adrenergic blockade increased plasma triglycerides but decreased high-density lipoprotein cholesterol. Cardioselective drugs (atenolol and metoprolol) had less effect on triglyceride and very low-density lipoprotein cholesterol than the nonselective beta blockers (propranolol and oxprenolol). Inhibition of lipoprotein lipase was suggested by a reduction of the fractional removal rate of triglyceride in conjunction with increased total and very low-density lipoprotein cholesterol levels and reduced high-density lipoprotein cholesterol. Consistent decreases in free fatty acids lend argument against elevated triglyceride synthesis.
研究了具有不同程度选择性和内在拟交感活性的β受体阻滞剂对血脂的影响。研究了脂质因子变化、脂蛋白脂肪酶功能、反应程度和治疗前特征之间的相互关系。β肾上腺素能阻断增加血浆甘油三酯，但降低高密度脂蛋白胆固醇。心脏选择性药物（阿替洛尔和美托洛尔）对甘油三酯和极低密度脂蛋白胆固醇的影响小于非选择性β受体阻滞剂（普萘洛尔和氧烯洛尔）。甘油三酯清除率分数降低，同时总胆固醇和极低密度脂蛋白胆固醇水平升高以及高密度脂蛋白胆固醇降低，提示脂蛋白脂肪酶受到抑制。游离脂肪酸持续下降，这与甘油三酯合成增加的观点相悖。
