Plans P, Pardell H, Salleras L
General Direction of Public Health, Department of Health, Autonomous Government of Catalonia, Barcelona, Spain.
Eur J Epidemiol. 1993 Jul;9(4):381-9. doi: 10.1007/BF00157394.
Cardiovascular disease is one of the most important public health problems in developed countries. We have studied the epidemiology of the following cardiovascular disease risk factors in a random sample (n = 704) of the adult population of Catalonia (Spain): hypercholesterolemia (> or = 6.1) mmol/l or 240 mg/dl), hypertension (SBP > or = 160 and/or DBP > or = 95 mmHg), low HDL-cholesterol concentrations (< 0.9 mmol/l or 35 mg/dl), hypertriglyceridemia (> 2.8 mmol/l or 250 mg/dl), obesity (BMI > 30), smoking and history of diabetes and coronary heart disease. Two percent of participants had hypertriglyceridemia, 3% had a history of coronary heart disease, 4% a history of diabetes, 6% low HDL-cholesterol concentrations, 12% were obese, 20% had hypertension, 24% had hypercholesterolemia and 36% were smokers. 58% of hypertensive individuals had been previously detected, 46% were currently on treatment, and 21% had their blood pressure controlled (SBP < 160 and DBP < 95 mmHg). Correlation and multiple regression analyses were used to investigate the association between cardiovascular risk factors. Multiple linear regression analysis showed independent correlations between risk factors. Prevalence of hypercholesterolemia, obesity and diabetes was higher and prevalence of smoking was lower in hypertensives than normotensives. The odds ratio was 3.68 (95% CI = 2.07-6.54) for hypercholesterolemia, 3.26 (95% CI = 1.52-7.02) for obesity, 3.81 (95% CI = 1.09-7.02) for diabetes and 0.40 (95% CI = 0.22-0.70) for smoking. The adjusted odds ratio was statistically significant for hypercholesterolemia (OR = 2.74, 95% CI = 1.01-3.75). The prevalence of cardiovascular risk factors was similar to that observed in other Mediterranean communities.(ABSTRACT TRUNCATED AT 250 WORDS)
心血管疾病是发达国家最重要的公共卫生问题之一。我们对西班牙加泰罗尼亚成年人群的一个随机样本(n = 704)进行了以下心血管疾病风险因素的流行病学研究:高胆固醇血症(≥6.1 mmol/l或240 mg/dl)、高血压(收缩压≥160和/或舒张压≥95 mmHg)、低高密度脂蛋白胆固醇浓度(<0.9 mmol/l或35 mg/dl)、高甘油三酯血症(>2.8 mmol/l或250 mg/dl)、肥胖(体重指数>30)、吸烟以及糖尿病和冠心病病史。2%的参与者患有高甘油三酯血症,3%有冠心病病史,4%有糖尿病病史,6%有低高密度脂蛋白胆固醇浓度,12%肥胖,20%患有高血压,24%患有高胆固醇血症,36%吸烟。58%的高血压患者之前已被诊断,46%正在接受治疗,21%的血压得到控制(收缩压<160且舒张压<95 mmHg)。采用相关性和多元回归分析来研究心血管风险因素之间的关联。多元线性回归分析显示风险因素之间存在独立相关性。与血压正常者相比,高血压患者中高胆固醇血症、肥胖和糖尿病的患病率更高,吸烟的患病率更低。高胆固醇血症的优势比为3.68(95%置信区间 = 2.07 - 6.54),肥胖为3.26(95%置信区间 = 1.52 - 7.02),糖尿病为3.81(95%置信区间 = 1.09 - 7.02),吸烟为0.40(95%置信区间 = 0.22 - 0.70)。高胆固醇血症的校正优势比具有统计学意义(优势比 = 2.74,95%置信区间 = 1.01 - 3.75)。心血管风险因素的患病率与其他地中海社区观察到的相似。(摘要截短至250字)