Palatnik C M, Wilkins C, Jacobson A
Cell. 1984 Apr;36(4):1017-25. doi: 10.1016/0092-8674(84)90051-5.
A rapid decrease in the translational efficiency of mRNA synthesized during vegetative growth is associated with the initiation of development in Dictyostelium discoideum. In contrast, newly synthesized mRNA associates with polysomes with high efficiency. Discrimination between these two mRNA populations correlates with a rapid shortening of the poly(A) tract on the preexisting mRNA. A model is proposed in which a critical poly(A) length regulates the pattern of protein synthesis by affecting the efficiency with which mRNAs can interact with the translational machinery. The model suggests that transcriptional and translational controls can be coupled by altering the state of adenylation of the preexisting mRNA population. The model allows radical changes in the pattern of protein synthesis without wholesale destruction of preexisting mRNA.
在盘基网柄菌营养生长期间合成的mRNA翻译效率迅速下降，这与发育的起始相关。相比之下，新合成的mRNA能高效地与多核糖体结合。这两类mRNA群体之间的区分与已存在mRNA上多聚腺苷酸尾的迅速缩短相关。我们提出了一个模型，其中一个关键的多聚腺苷酸长度通过影响mRNA与翻译机制相互作用的效率来调节蛋白质合成模式。该模型表明，转录和翻译控制可以通过改变已存在mRNA群体的腺苷酸化状态来耦合。该模型允许蛋白质合成模式发生根本性变化，而无需大规模破坏已存在的mRNA。
