Giacosa A, Parodi M C, Molinari F, Cheli R
Int J Tissue React. 1983;5(4):403-6.
The effect of somatostatin (250 mcg. by i.v. bolus injection) on serum gastrin behaviour was studied in 12 dyspeptic subjects. In 6 of them, seven gastrin levels were determined in the basal conditions and after somatostatin injection. In the remaining 6 patients, the gastrinemic profile was evaluated after histamine injection (0.5 mg/i.m.) and after the injection of histamine plus somatostatin (24 h later). Gastric acid secretion was also determined in all the cases. The results obtained demonstrate that somatostatin reduces the gastrin release: this reduction appears 30 minutes after its administration and persists until the 60th minute: after the 75th minute the serum gastrin returns to the basal level. The contemporaneous injection of somatostatin and of histamine does not modify the gastrinemic profile as compared to what was observed in the basal condition or after histamine alone.
在12名消化不良患者中研究了生长抑素（静脉推注250微克）对血清胃泌素行为的影响。其中6名患者在基础状态和注射生长抑素后测定了7次胃泌素水平。其余6名患者在注射组胺（0.5毫克/肌肉注射）后以及注射组胺加生长抑素（24小时后）评估了胃泌素血症情况。所有病例均测定了胃酸分泌。获得的结果表明，生长抑素可减少胃泌素释放：这种减少在给药后30分钟出现并持续至第60分钟：75分钟后血清胃泌素恢复至基础水平。与基础状态或单独注射组胺后观察到的情况相比，同时注射生长抑素和组胺不会改变胃泌素血症情况。
