Ratković M, Novaković R, Secen S
Klinicko-bolnicki centar Dr Dragisa Misovic, Beograd, Klinika za internu medicinu.
Med Pregl. 1995;48(5-6):149-51.
Serum levels of gastrin, somatostatin and vasoactive intestinal polypeptide were evaluated in 105 noninsulin dependent diabetics (25 of them had a pyloric dysfunction). The serum levels were determined by RIA and blood was taken before and after the test meal. The basal gastrin level was significantly higher in patients with the pyloric dysfunction (p < 0.001). 45 minutes later the serum levels of vasoactive intestinal polypeptide and somatostatin were significantly higher in diabetics with the pyloric dysfunction (p < 0.001). The serum levels of gastrin, somatostatin and vasoactive intestinal polypeptide were impaired in diabetics with the pyloric dysfunction and might be associated with its pathogenesis.
对105例非胰岛素依赖型糖尿病患者（其中25例有幽门功能障碍）的胃泌素、生长抑素和血管活性肠肽血清水平进行了评估。通过放射免疫分析法测定血清水平，并在试餐前后采集血液。幽门功能障碍患者的基础胃泌素水平显著更高（p<0.001）。45分钟后，有幽门功能障碍的糖尿病患者的血管活性肠肽和生长抑素血清水平显著更高（p<0.001）。有幽门功能障碍的糖尿病患者的胃泌素、生长抑素和血管活性肠肽血清水平受损，可能与其发病机制有关。
