Strodel W E, Vinik A I, Lloyd R V, Glaser B, Eckhauser F E, Fiddian-Green R G, Turcotte J G, Thompson N W
Arch Surg. 1984 May;119(5):508-14. doi: 10.1001/archsurg.1984.01390170008003.
Eight patients with pancreatic polypeptide (PP)-producing islet cell tumors and one patient with pseudo-PP-producing tumors were examined. Their age range was 20 to 74 years. Clinical features included abdominal pain in four patients, weight loss in four patients, diarrhea in two patients, gastrointestinal bleeding in two patients, and jaundice in one patient. The range of the basal serum level of PP was 394 to 35,100 pg/mL. In two patients the PP-producing tumors were associated with multiple endocrine neoplasia. Two patients had diffuse hepatic metastases at the time of diagnosis and four patients had disease limited to the pancreas. Pancreaticoduodenectomy and 80% pancreatectomy were performed in four and two patients, respectively. Immunohistochemical staining was positive for PP and neuron-specific enolase in all cases and was negative for other peptides except in one specimen with microadenomatosis. Patients who underwent curative resection are asymptomatic with normal serum levels of PP.
对8例产生胰多肽（PP）的胰岛细胞瘤患者和1例产生假性PP的肿瘤患者进行了检查。他们的年龄范围为20至74岁。临床特征包括4例腹痛、4例体重减轻、2例腹泻、2例胃肠道出血和1例黄疸。基础血清PP水平范围为394至35100 pg/mL。2例产生PP的肿瘤与多发性内分泌肿瘤相关。2例患者在诊断时已有弥漫性肝转移，4例患者疾病局限于胰腺。分别对4例和2例患者实施了胰十二指肠切除术和80%胰腺切除术。所有病例免疫组化染色PP和神经元特异性烯醇化酶均为阳性，除1例微腺瘤病标本外，其他肽类均为阴性。接受根治性切除的患者无症状，血清PP水平正常。
