Rhoads D E, DiRocco R J, Osburn L D, Peterson N A, Raghupathy E
Biochem Biophys Res Commun. 1984 Mar 30;119(3):1198-204. doi: 10.1016/0006-291x(84)90903-3.
Insulin stimulates in a dose-dependent manner (concentration range of 0.1 - 10 microM) the synaptosomal uptake of amino acids characterized by high-affinity, Na+-dependent, veratridine-sensitive transport systems. This stimulation is observed in synaptosomes prepared from each of several regions of the adult rat brain. Both the initial rate of amino acid uptake and the overall capacity for amino acid accumulation are increased. Since these transport systems have been associated with the neurotransmitter role of the amino acids, we postulate that insulin can modulate neurotransmission in the rat central nervous system by increasing the efficiency of neuroactive amino acid reuptake.
胰岛素以剂量依赖性方式（浓度范围为0.1 - 10微摩尔）刺激突触体对氨基酸的摄取，其特征为高亲和力、钠依赖性、藜芦碱敏感的转运系统。在成年大鼠脑的几个不同区域制备的突触体中均观察到这种刺激作用。氨基酸摄取的初始速率和氨基酸积累的总体能力均有所增加。由于这些转运系统与氨基酸的神经递质作用相关，我们推测胰岛素可通过提高神经活性氨基酸再摄取的效率来调节大鼠中枢神经系统中的神经传递。
