Phares C K, Carroll R M
J Helminthol. 1984 Mar;58(1):25-30. doi: 10.1017/s0022149x00028017.
Elevated serum lipids are associated with infections of laboratory rodents with plerocercoids of Spirometra mansonoides. The effect of infection with these larval tapeworms on triglyceride degradation and hepatic de novo fatty acid synthesis was investigated in Syrian hamsters. Serum lipoprotein electrophoresis revealed a consistent elevation in very low density lipoproteins in the infected animals. Lipoprotein lipase activity was enhanced in the infected animals. After seven days of plerocercoid infection the activity of acetyl-CoA carboxylase (E.C. 6.4.1.2) was significantly elevated after 6, 12 and 18 hours of fasting. Fatty acid synthetase was significantly increased after 0, 6, 12, 18 and 24 hours of fasting. Therefore, a chronic insulin-like activity on lipid metabolism of hamsters is associated with plerocercoid infection.
血清脂质升高与实验室啮齿动物感染曼氏迭宫绦虫裂头蚴有关。在叙利亚仓鼠中研究了这些幼虫绦虫感染对甘油三酯降解和肝脏从头脂肪酸合成的影响。血清脂蛋白电泳显示感染动物的极低密度脂蛋白持续升高。感染动物的脂蛋白脂肪酶活性增强。在裂头蚴感染七天后，禁食6、12和18小时后，乙酰辅酶A羧化酶（E.C. 6.4.1.2）的活性显著升高。禁食0、6、12、18和24小时后，脂肪酸合成酶显著增加。因此，仓鼠脂质代谢的慢性胰岛素样活性与裂头蚴感染有关。
