Seino Y, Seino S, Usami M, Tsuda K, Takemura J, Nishi S, Ishida H, Imura H
Metabolism. 1984 May;33(5):429-31. doi: 10.1016/0026-0495(84)90142-2.
Insulin, somatostatin, and glucagon release from the perfused pancreas was studied in the newly developed genetically obese hyperglycemic hyperinsulinemic (Wistar fatty) rat. Insulin and somatostatin levels rose significantly compared to those in lean littermate controls during arginine infusion. The glucagon increase, however, was significantly less when total amounts during arginine infusion were calculated. These results show that hypersecretion of insulin and somatostatin in vitro may suppress glucagon release in Wistar fatty rats.
在新培育的遗传性肥胖高血糖高胰岛素血症（Wistar肥胖）大鼠中，研究了灌注胰腺中胰岛素、生长抑素和胰高血糖素的释放情况。与瘦的同窝对照大鼠相比，在精氨酸输注期间，胰岛素和生长抑素水平显著升高。然而，当计算精氨酸输注期间的总量时，胰高血糖素的增加明显较少。这些结果表明，体外胰岛素和生长抑素的高分泌可能会抑制Wistar肥胖大鼠中胰高血糖素的释放。
