Bowers M B
Eur J Pharmacol. 1984 Mar 16;99(1):103-5. doi: 10.1016/0014-2999(84)90438-2.
Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex 3 h following a single dose of a variety of neuroleptics. Thioridazine, haloperidol, fluphenazine, and metoclopramide increased HVA levels in caudate more than in pre-frontal cortex; whereas sulpiride and clozapine produced greater increases in HVA in pre-frontal cortex. These results are consistent with the proposal that rat pre-frontal cortex is relatively deficient in dopamine autoreceptors.
在给予大鼠单次剂量的多种抗精神病药物3小时后，测定其尾状核和前额叶皮质中的高香草酸（HVA）。硫利达嗪、氟哌啶醇、氟奋乃静和甲氧氯普胺使尾状核中HVA水平的升高幅度大于前额叶皮质；而舒必利和氯氮平使前额叶皮质中HVA的升高幅度更大。这些结果与大鼠前额叶皮质中多巴胺自身受体相对缺乏的观点一致。
