Bowers M B, Rozitis A
Eur J Pharmacol. 1976 Sep;39(1):109-15. doi: 10.1016/0014-2999(76)90118-7.
Acute administration of equivalent doses of either chlorpromazine, thioridazine, or clozapine, respectively, produced progressively smaller increases in brain homovanillic acid (HVA) in the rabbit; however, changes in HVA in three brain regions were of equal magnitude for a single dose of a given drug. Chronic administration of fluphenazine enanthate resulted in a decrease in HVA relative to acute treatment in caudate more than limbic regions. No differences between caudate and limbic regions were observed during daily chlorpromazine administration for 3 ro 8 days. Tolerance appeared to develop in approximately 1 week. Chronic treatment with clozapine produced no tolerance at one week but suggestive evidence of tolerance in caudate and limbic regions at two weeks. No tolerance was observed in the hypothalamus during chronic treatment with any drug used. Cisternal CSF HVA paralleled caudate HVA during acute and chronic treatments.
分别急性给予等效剂量的氯丙嗪、硫利达嗪或氯氮平，家兔脑内高香草酸（HVA）的增加量逐渐减小；然而，对于给定药物的单剂量，三个脑区HVA的变化幅度相同。与急性治疗相比，慢性给予氟奋乃静庚酸酯导致尾状核中HVA的降低比边缘区更明显。在连续3至8天给予氯丙嗪期间，未观察到尾状核和边缘区之间的差异。耐受性似乎在大约1周内形成。氯氮平慢性治疗1周时未产生耐受性，但在2周时尾状核和边缘区有耐受性的提示性证据。在使用任何药物进行慢性治疗期间，下丘脑均未观察到耐受性。在急性和慢性治疗期间，脑池脑脊液HVA与尾状核HVA平行。
