双氟尼酸与家兔的血液酸碱状态

Diflunisal and blood acid base status in the rabbit.

作者信息

Smith J E, Bradshaw E G, Pleuvry B J

出版信息

J Pharm Pharmacol. 1984 Mar;36(3):167-70. doi: 10.1111/j.2042-7158.1984.tb06932.x.

DOI:10.1111/j.2042-7158.1984.tb06932.x

Abstract

Both diflunisal and acetylsalicylic acid given orally caused respiratory alkalosis and metabolic acidosis. However the fall in standard bicarbonate was much less in diflunisal-treated rabbits and pH in these animals remained elevated for the duration of the experiment. Whilst the severity of the fall in arterialized venous PCO2 was a good indicator of the degree of acetylsalicylic acid intoxication this was not the case for diflunisal as fatalities occurred with trivial changes in PCO2. Diflunisal toxicity was associated with markedly elevated temperatures. This was not observed in acetylsalicylic acid-treated rabbits.

摘要

口服双氟尼酸和乙酰水杨酸均会导致呼吸性碱中毒和代谢性酸中毒。然而，双氟尼酸治疗组兔子的标准碳酸氢盐下降幅度要小得多，并且在实验期间这些动物的pH值一直保持升高。虽然动脉化静脉血PCO₂下降的严重程度是乙酰水杨酸中毒程度的良好指标，但双氟尼酸并非如此，因为在PCO₂仅有微小变化时就会发生死亡。双氟尼酸毒性与体温显著升高有关。在乙酰水杨酸治疗的兔子中未观察到这种情况。