Varhaug J E, Svanes K, Lekven J
Scand J Gastroenterol. 1983 Oct;18(7):977-86. doi: 10.3109/00365528309182126.
Experiments were performed in anesthetized cats. Tissue blood flow and cardiac output were measured by means of labeled microspheres. Cimetidine did not affect gastric blood flow at basal conditions. Pentagastrin stimulation more than doubled corpus-fundus mucosal blood flow (MBF). Cimetidine reduced pentagastrin-stimulated corpus-fundus MBF and acid output towards basal level. Recovery of acid secretion after inhibition by a bolus dose of cimetidine occurred without a corresponding restoration of MBF. Neither pentagastrin nor cimetidine significantly altered antrum MBF or muscularis blood flow. The study demonstrates that cimetidine reduces the ratio between pentagastrin-stimulated acid secretion and corpus-fundus MBF by lowering secretion considerably more than the corresponding MBF.
实验在麻醉猫身上进行。通过标记微球测量组织血流量和心输出量。在基础条件下，西咪替丁不影响胃血流量。五肽胃泌素刺激使胃体-胃底黏膜血流量（MBF）增加一倍以上。西咪替丁使五肽胃泌素刺激的胃体-胃底MBF和胃酸分泌降至基础水平。静脉推注西咪替丁抑制胃酸分泌后，胃酸分泌恢复，但MBF未相应恢复。五肽胃泌素和西咪替丁均未显著改变胃窦MBF或肌层血流量。该研究表明，西咪替丁通过大幅降低胃酸分泌而非相应降低MBF，降低了五肽胃泌素刺激的胃酸分泌与胃体-胃底MBF之间的比值。
