Finnström O, Ezitis J, Rydén G, Wichman K
Acta Obstet Gynecol Scand Suppl. 1984;118:91-3. doi: 10.3109/00016348409157131.
A review is presented as regards the neonatal effects of beta-blocking agents in hypertension during pregnancy. Experience points to low fetal and neonatal risks, but firmly based data concerning the neonates are very scanty. An on-going double-blind study is presented in which pregnant women with hypertension are randomly allocated to either metoprolol or placebo treatment. One of the aims is to study the postnatal adaptation of the infants. The following measurements, recordings and examinations are performed: anthropometric measurements, Apgar score, blood gases and acid-base status in umbilical (venous and arterial) blood, lactate and hypoxanthine in umbilical venous blood, catecholamines in umbilical arterial blood, pulse rate, blood glucose and a quantitative neurobehavioral assessment in the neonatal period.
本文对β受体阻滞剂在妊娠期高血压中的新生儿效应进行了综述。经验表明胎儿和新生儿风险较低，但关于新生儿的确凿数据非常稀少。文中介绍了一项正在进行的双盲研究，将患有高血压的孕妇随机分配接受美托洛尔或安慰剂治疗。目的之一是研究婴儿的产后适应性。进行了以下测量、记录和检查：人体测量、阿氏评分、脐血（静脉血和动脉血）的血气和酸碱状态、脐静脉血中的乳酸和次黄嘌呤、脐动脉血中的儿茶酚胺、心率、血糖以及新生儿期的定量神经行为评估。
