Perlman R, Guideri G
Arch Int Pharmacodyn Ther. 1984 Apr;268(2):202-15.
Blood pressure, heart rate and electrocardiogram were monitored in unanesthetized, unrestrained rats while the area of the locus coeruleus was stimulated by the injection of 0.03 to 10 micrograms of aconitine to pharmacologically evaluate its cardiovascular action. Aconitine elicited a dose-dependent elevation of mean blood pressure to 200 mmHg; at doses of 1-10 micrograms, it increased heart rate by more than 100 beats/min and produced arrhythmias. Phentolamine and the serotonergic antagonist, 2-bromo-lysergic acid diethylamide, prevented aconitine-induced cardiovascular changes. Diminution of aconitine-induced tachycardia by propranolol was attributed to the antagonist's direct peripheral effects. Atropine (5 mg/kg, subcutaneously) did not alter aconitine's cardiovascular actions. It is suggested that stimulation of the area of the locus coeruleus with aconitine elicits specific cardiovascular effects, which may involve adrenergic as well as serotonergic pathways.
在未麻醉、未束缚的大鼠身上监测血压、心率和心电图，同时通过注射0.03至10微克乌头碱刺激蓝斑区域，以药理学方式评估其心血管作用。乌头碱引起平均血压剂量依赖性升高至200 mmHg；在1 - 10微克剂量下，它使心率增加超过100次/分钟并产生心律失常。酚妥拉明和5 - 羟色胺拮抗剂2 - 溴麦角酸二乙酰胺可预防乌头碱引起的心血管变化。普萘洛尔对乌头碱引起的心动过速的减弱作用归因于该拮抗剂的直接外周效应。阿托品（5 mg/kg，皮下注射）未改变乌头碱的心血管作用。提示用乌头碱刺激蓝斑区域会引发特定的心血管效应，这可能涉及肾上腺素能以及5 - 羟色胺能途径。
