Wang M J, Huang C J, Zhang G S
Department of Physiology, Yunyang Medical College, Shiyan.
Sheng Li Xue Bao. 1995 Jun;47(3):297-300.
Experiments were carried out on 84 artifially ventilated SD rats anaesthetized with urethane and immobilized with gallamine triethiodide. Injection of pentagastrin (G5) into the rat lateral ventricle resulted in a marked elevation in arterial blood pressure which reached its peak at 3 min (from 12.2 +/- 1.5 to 14.1 +/- 1.7 kPa) and also a significant increase in heart rate from 435 +/- 53.9 to 471.6 +/- 53.2 beats/min. This effect of G5 could be partially antagonized by injection of phentolamine (alpha-receptor antagonist, 10 micrograms) into the lateral ventricle, but not by propanolol (beta-receptor antagonist, 4 micrograms) or atropine (M-receptor antagonist, 4 micrograms). These findings indicate that the central effect of G5 on blood pressure and heart rate is partly mediated by alpha-receptor.
实验在84只使用乌拉坦麻醉并用三碘季铵酚固定的人工通气的SD大鼠身上进行。向大鼠侧脑室内注射五肽胃泌素（G5）导致动脉血压显著升高，在3分钟时达到峰值（从12.2±1.5kPa升至14.1±1.7kPa），同时心率也显著增加，从435±53.9次/分钟增至471.6±53.2次/分钟。G5的这种作用可通过向侧脑室内注射酚妥拉明（α受体拮抗剂，10微克）而部分拮抗，但不能被普萘洛尔（β受体拮抗剂，4微克）或阿托品（M受体拮抗剂，4微克）拮抗。这些发现表明，G5对血压和心率的中枢作用部分是由α受体介导的。
