Pfadenhauer E H, Bankert C S, Jensen J, Jones C E, Jenkins E E, McCloskey J A
Drug Metab Dispos. 1984 May-Jun;12(3):280-4.
After administration of erythro-9-(2-hydroxy-3-nonyl)hypoxanthine, eight compounds were isolated from the urine of rats, dogs, and monkeys. All of the drug metabolites were modified on the nonyl side chain. The oxidatively degraded metabolites included an alcohol (9-(2,8-dihydroxy-3-nonyl)hypoxanthine), the corresponding ketone (erythro-9-(2-hydroxy-8-keto-3-nonyl)hypoxanthine), and three carboxylic acids [erythro-6-hydroxy-5-(9- hypoxanthyl ) hepanoic acid, erythro-7-hydroxy-6-(9- hypoxanthyl )octanoic acid, and erythro-8-hydroxy-7-(9- hypoxanthyl )nonanoic acid]. Glucuronide conjugates of the unchanged drug and the alcohol metabolite were also found. The alcohol, ketone, and nonanoic acid metabolites were produced by all three species. Only the rat produced the shorter chain acid derivatives and no glucuronides. The monkey excreted both glucuronides, while dogs formed one glucuronide conjugate, that of the parent drug.
给予erythro-9-(2-羟基-3-壬基)次黄嘌呤后，从大鼠、狗和猴子的尿液中分离出8种化合物。所有药物代谢物均在壬基侧链上发生了修饰。氧化降解代谢物包括一种醇（9-(2,8-二羟基-3-壬基)次黄嘌呤）、相应的酮（erythro-9-(2-羟基-8-氧代-3-壬基)次黄嘌呤）和三种羧酸[erythro-6-羟基-5-(9-次黄嘌呤基)庚酸、erythro-7-羟基-6-(9-次黄嘌呤基)辛酸和erythro-8-羟基-7-(9-次黄嘌呤基)壬酸]。还发现了未变化药物和醇代谢物的葡萄糖醛酸共轭物。醇、酮和壬酸代谢物由所有三个物种产生。只有大鼠产生了较短链的酸衍生物，且未产生葡萄糖醛酸共轭物。猴子排泄出两种葡萄糖醛酸共轭物，而狗形成了一种葡萄糖醛酸共轭物，即母体药物的共轭物。
