Baggio B, Gambaro G, Marchini F, Cicerello E, Borsatti A
Lancet. 1984 Jul 7;2(8393):12-3. doi: 10.1016/s0140-6736(84)91998-6.
Red-blood-cell transmembrane oxalate flux was measured in a group of patients with idiopathic calcium oxalate nephrolithiasis and in normal controls. The mean transmembrane oxalate flux rate was significantly higher in stone-forming patients than in controls (0.93 +/- SD 0.31/min vs 0.29 +/- 0.11/min). 80% of stone-forming patients showed raised (greater than 2SD above the mean in controls) transmembrane oxalate flux. Anomalous cellular oxalate transport may be an important pathogenetic factor in calcium oxalate nephrolithiasis.
对一组特发性草酸钙肾结石患者和正常对照者测量了红细胞跨膜草酸通量。结石形成患者的平均跨膜草酸通量率显著高于对照组（分别为0.93±标准差0.31/分钟和0.29±0.11/分钟）。80%的结石形成患者显示跨膜草酸通量升高（高于对照组平均值2个标准差以上）。异常的细胞草酸转运可能是草酸钙肾结石的一个重要致病因素。
