Roehrs T, Lamphere J, Paxton C, Wittig R, Zorick F, Roth T
Br J Clin Pharmacol. 1984 Jun;17(6):691-6. doi: 10.1111/j.1365-2125.1984.tb02405.x.
The hypnotic efficacy of temazepam capsules (30 mg) was studied in twelve patients who had objective polysomnographic evidence of sleep onset insomnia. Patients slept in the laboratory, retiring at their usual bedtime after taking placebo or temazepam 30 min earlier, and were monitored for 8 h using standard polysomnographic techniques. Acute (nights 5-7) and chronic (nights 11-13) temazepam improved the sleep of these patients by reducing sleep latency and increasing sleep time compared to the placebo baseline (nights 2-4). No detrimental effects on daytime function the following morning were observed using questionnaires and objective tests of performance. No consistent evidence of disturbed sleep after discontinuation of treatment was obtained over three recovery nights.
在12名有客观多导睡眠图证据表明存在入睡性失眠的患者中，研究了替马西泮胶囊（30毫克）的催眠疗效。患者在实验室睡觉，在比平时就寝时间提前30分钟服用安慰剂或替马西泮后按其平常就寝时间上床休息，并使用标准多导睡眠图技术监测8小时。与安慰剂基线期（第2 - 4晚）相比，急性（第5 - 7晚）和慢性（第11 - 13晚）替马西泮通过缩短睡眠潜伏期和增加睡眠时间改善了这些患者的睡眠。使用问卷和客观性能测试未观察到对次日早晨日间功能的有害影响。在三个恢复夜晚期间，未获得停药后睡眠紊乱的一致证据。
