Richelson E
J Clin Psychiatry. 1984 Aug;45(8):331-6.
Affinities of some antipsychotic drugs for 5 human brain receptors (dopamine D-2, muscarinic acetylcholine, histamine H1, alpha 1-adrenergic, and alpha 2-adrenergic receptors) were obtained using radioligand binding techniques. Seventeen drugs were studied at the D-2 receptor; 15 at the remaining receptors. These drugs showed marked differences in affinities at most receptors, and these differences may help explain variations in their propensities to cause certain adverse effects in patients. The clinical efficacy of all neuroleptics appears to be equal. Thus, these differences allow the clinician to choose drugs with low affinity for certain receptors and, thereby, minimize some of the adverse effects of these drugs in patients.
利用放射性配体结合技术获得了一些抗精神病药物对5种人脑受体（多巴胺D-2、毒蕈碱型乙酰胆碱、组胺H1、α1-肾上腺素能和α2-肾上腺素能受体）的亲和力。对17种药物进行了D-2受体研究；对其余受体研究了15种药物。这些药物在大多数受体上显示出明显的亲和力差异，这些差异可能有助于解释它们在患者中引起某些不良反应倾向的变化。所有抗精神病药物的临床疗效似乎相当。因此，这些差异使临床医生能够选择对某些受体亲和力低的药物，从而将这些药物对患者的一些不良反应降至最低。
