巯基试剂对豚鼠离体回肠对各种激动剂反应的增强作用。

Potentiation by sulphydryl agents of the responses of guinea-pig isolated ileum to various agonists.

作者信息

Fontaine J, Famaey J P, Reuse J

出版信息

J Pharm Pharmacol. 1984 Jul;36(7):450-3. doi: 10.1111/j.2042-7158.1984.tb04423.x.

DOI:10.1111/j.2042-7158.1984.tb04423.x

Abstract

Sulphydryl agents (dithiothreitol, mercaptoethanol, monothioglycerol, cysteine, glutathione) increase non-specifically the potency of various agonists (acetylcholine, 5-hydroxytryptamine, nicotine, bradykinin, prostaglandin E2) on the guinea-pig ileum. These effects are of non-cholinergic origin and are not related to prostaglandin synthesis. Sulphydryl agents act directly on the smooth muscle cells of the guinea-pig ileum most probably by reducing disulphide bonds located on the membrane surface and by this mechanism modulate the muscular contractile activity.

摘要

巯基试剂（二硫苏糖醇、巯基乙醇、单硫甘油、半胱氨酸、谷胱甘肽）可非特异性地增强多种激动剂（乙酰胆碱、5-羟色胺、尼古丁、缓激肽、前列腺素E2）对豚鼠回肠的作用效力。这些作用源自非胆碱能，且与前列腺素合成无关。巯基试剂最有可能通过还原位于膜表面的二硫键，直接作用于豚鼠回肠的平滑肌细胞，并以此机制调节肌肉收缩活动。