Siubaev R D, Shvarts G Ia
Biull Eksp Biol Med. 1984 Jul;98(7):48-51.
It has been demonstrated in rat experiments that the beta-adrenoblockers propranolol and pindolol differ in the influence on the therapeutic and toxic effects of voltaren and acetylsalicylic acid. Propranolol has an analgetic action of its own, reducing the analgetic and antiinflammatory effects of voltaren and acetylsalicylic acid. It potentiates the antipyretic effect of voltaren and ulcerogenic action of both nonsteroidal antiinflammatory drugs. Pindolol exerts both analgetic and antiinflammatory action and does not affect the antipyretic effect of voltaren and ulcerogenic action of nonsteroidal antiinflammatory drugs. The difference in the action of the beta-adrenoblockers under study is likely to be linked with the characteristics of their pharmacological action spectrum.
大鼠实验表明，β-肾上腺素能阻滞剂普萘洛尔和吲哚洛尔对扶他林和乙酰水杨酸的治疗作用及毒性作用的影响有所不同。普萘洛尔自身具有镇痛作用，会降低扶他林和乙酰水杨酸的镇痛及抗炎作用。它增强了扶他林的解热作用以及两种非甾体抗炎药的致溃疡作用。吲哚洛尔兼具镇痛和抗炎作用，且不影响扶他林的解热作用及非甾体抗炎药的致溃疡作用。所研究的β-肾上腺素能阻滞剂作用的差异可能与其药理作用谱的特点有关。
