Ryhänen R, Herranen J, Korhonen K, Penttilä I, Polvilampi M, Puhakainen E
Int J Biochem. 1984;16(6):687-90. doi: 10.1016/0020-711x(84)90039-9.
The activities of serum pseudocholinesterase, lecithin: cholesterol acyltransferase (LCAT) and gamma-glutamyltransferase in rabbits were investigated before and after dichlorvos administration in vivo. The effects of this organophosphate on some serum lipids and lipoprotein fractions were also determined. LCAT activity remained almost unaffected after organophosphate administration. However, serum gamma-glutamyltransferase and pseudocholinesterase activities markedly decreased. Dichlorvos markedly lowered both serum low density lipoprotein (LDL) and cholesterol contents, whereas high density lipoprotein (HDL) concentration increased and very low density lipoprotein (VLDL) remained unaffected. Triglycerides as well as esterified fatty acids increased significantly but the statistical changes in free fatty acid concentrations were not significant, because individual variations in fatty acid concentrations were high.
在体内给予家兔敌敌畏前后，对其血清假性胆碱酯酶、卵磷脂胆固醇酰基转移酶（LCAT）和γ-谷氨酰转移酶的活性进行了研究。还测定了这种有机磷对某些血脂和脂蛋白组分的影响。给予有机磷后，LCAT活性几乎未受影响。然而，血清γ-谷氨酰转移酶和假性胆碱酯酶活性显著降低。敌敌畏显著降低了血清低密度脂蛋白（LDL）和胆固醇含量，而高密度脂蛋白（HDL）浓度升高，极低密度脂蛋白（VLDL）未受影响。甘油三酯以及酯化脂肪酸显著增加，但游离脂肪酸浓度的统计学变化不显著，因为脂肪酸浓度的个体差异很大。
