Chetty K N, Walker J, Brown K, Ivie G W
Department of Biological Sciences, Grambling State University, Louisiana 71245.
Arch Environ Contam Toxicol. 1993 Apr;24(3):365-7. doi: 10.1007/BF01128735.
Male, Sprague-Dawley rats were treated with 0, 1, 10, 50, 100 ppm chlordecone (Cd) mixed in calcium-sufficient (Ca-S) or calcium-deficient (Ca-D) diet for 15 days. A significant decrease in body weight gain was observed in 100 ppm of Cd-treated rats. Cholinesterase (ChE) activity was significantly decreased in serum of Ca-D rats. Chlordecone did not alter serum ChE activity in both Ca-S and Ca-D rats. However, Cd decreases serum triglycerides, low density lipoproteins (LDL) and cholesterol in both Ca-S and Ca-D rats. Rats fed with Ca-S or Ca-D diet exhibited differential sensitivity to Cd-toxicity. Decreased levels of serum triglycerides, LDL and cholesterol suggest that Cd might interfere in lipid metabolism.
雄性Sprague-Dawley大鼠分别用0、1、10、50、100 ppm的开蓬（Cd）混入钙充足（Ca-S）或钙缺乏（Ca-D）的饮食中，持续处理15天。在接受100 ppm Cd处理的大鼠中观察到体重增加显著下降。钙缺乏大鼠血清中的胆碱酯酶（ChE）活性显著降低。开蓬在钙充足和钙缺乏的大鼠中均未改变血清ChE活性。然而，镉降低了钙充足和钙缺乏大鼠的血清甘油三酯、低密度脂蛋白（LDL）和胆固醇。喂食钙充足或钙缺乏饮食的大鼠对镉毒性表现出不同的敏感性。血清甘油三酯、LDL和胆固醇水平的降低表明镉可能干扰脂质代谢。
