硫胺素缺乏所致的严重乳酸酸中毒：急性恶性或暴发性脚气病。

Lancet. 1984 Aug 25;2(8400):446-9. doi: 10.1016/s0140-6736(84)92918-0.

Adults who had been drinking alcohol were admitted to hospital with severe lacticacidosis and died within two days. Empirical treatment with thiamine proved to be a cure for the disorder, for it was acute pernicious or fulminating beriberi. Thiamine deficiency is neglected as a cause of lacticacidosis.

饮酒的成年人因严重乳酸酸中毒入院，并在两天内死亡。经验性使用硫胺素治疗被证明是治愈该病症的方法，因为这是急性恶性或暴发性脚气病。硫胺素缺乏作为乳酸酸中毒的一个原因被忽视了。