Papasova M, Velkova V, Atanassova E
Acta Physiol Pharmacol Bulg. 1977;3(4):3-11.
Experiments are carried out on dogs with chronically implanted leading-off electrodes on both sides of the transection at the level of the proximal duodenum. A pair of stimulating electrodes are also implanted below the transection. Electrical stimulation with impulses synchronized with the slow waves generated by the segment proximal to the section (amplitude 3-7 V, delay 0.2 s and duration 0.5 s) as well as with periodic impulses (18-21 cpm, duration 0.2-0.5 s and amplitude 3-10 V) results in shortening of the period T of several slow waves from the distal segment. Subsequently the frequency of the slow waves from this segment approaches that of the proximal segment. The restoration of the slow-wave plateau at the beginning of the small intestine depends both on the amplitude and on the frequency of the stimulating impulses. On the background of antagonists of the cholinergic (atr. sulf. 200 microgram/kg) and of the adrenergic systems (propranolol 2 mg/kg and phentolamine 1 mg/kg), increasing the frequency of the slow waves of the segment which is distal to the section requires an increase in the amplitude of the stimulating impulses. The role of the intrinsic nervous system for the assimilation of the slow-wave rhythm from the distal segment by the proximal one is discussed.
实验在狗身上进行，在十二指肠近端水平的横断处两侧长期植入引出电极。在横断下方还植入一对刺激电极。用与横断近端节段产生的慢波同步的脉冲（幅度3 - 7V，延迟0.2s，持续时间0.5s）以及周期性脉冲（18 - 21次/分钟，持续时间0.2 - 0.5s，幅度3 - 10V）进行电刺激，会导致远端节段几个慢波的周期T缩短。随后，该节段慢波的频率接近近端节段的频率。小肠起始处慢波平台的恢复既取决于刺激脉冲的幅度，也取决于其频率。在胆碱能拮抗剂（硫酸阿托品200微克/千克）和肾上腺素能系统拮抗剂（普萘洛尔2毫克/千克和酚妥拉明1毫克/千克）的作用下，要增加横断远端节段慢波的频率，需要提高刺激脉冲的幅度。文中讨论了内在神经系统在近端节段同化远端节段慢波节律方面的作用。
