Atanassova E, Solovyova I, Papasova M, Kortezova N
Acta Physiol Pharmacol Bulg. 1978;4(2):3-12.
Experiments are carried out on dogs with transection of the duodenum followed by end-to-end anastomosis and chronically implanted silver ball-shaped electrodes on the muscle wall of the stomach and on the segments of the duodenum proximal and distal to the transection. Dissociation of the spike activity of the two duodenal segments is established after the operation. As early as the second week after the transection, parallel with this single group of spike potentials propagating through the anastomosis are also observed. With increasing the time interval from the operation propagation of the spike activity along the length of the muscle occurs more and more frequently. The difference in the percentage of spike activity of the two duodenal segments is greatest during the first and second months after the operation. At the beginning of the third month it decreases gradually to reach 10 per cent approximately during the fifth month after the operation. In preliminary vagotomized dogs the difference in the percentage of the spike activity is maintained around 20-30 per cent. In dogs with definitely separated segment of the duodenum this difference becomes great and there are no tendencies towards reduction even in the sixth month post operation. Histological studies of the material taken from the area of the anastomosis of animals at different post-transection periods, subjected to silver impregnation after the method of Bielschowsky-Gross, show regeneration of the severed nerve bundles of plexus myentericus Auerbachi. The restoration of the spreading of the spike activity along the length of the duodenum is associated with restoration of the nerve structures in the muscle wall of the duodenum.
对狗进行实验，先横断十二指肠，然后进行端端吻合，并在胃肌壁以及横断处近端和远端的十二指肠段长期植入银质球形电极。术后发现两个十二指肠段的锋电位活动出现分离。早在横断后的第二周，就观察到与通过吻合口传播的这一组单一锋电位并行的情况。随着术后时间间隔的增加，锋电位活动沿肌肉长度的传播越来越频繁。术后第一个月和第二个月，两个十二指肠段锋电位活动的百分比差异最大。在第三个月初，差异逐渐减小，在术后第五个月左右降至约10%。在预先切断迷走神经的狗中，锋电位活动百分比的差异维持在20% - 30%左右。在十二指肠段明显分离的狗中，这种差异变得很大，即使在术后第六个月也没有减小的趋势。对不同横断后时期动物吻合口区域取材的组织进行研究，采用 Bielschowsky - Gross 方法进行银浸染，结果显示奥尔巴赫肠肌丛切断的神经束发生了再生。十二指肠锋电位活动沿长度传播的恢复与十二指肠肌壁神经结构的恢复相关。
