Meade T W, Howarth D J, Stirling Y, Welch T P, Crompton M R
Lancet. 1984 Sep 15;2(8403):607-9. doi: 10.1016/s0140-6736(84)90597-x.
Fibrinopeptide A (FPA) concentrations were measured in blood taken by direct cardiac puncture from 31 patients who had died suddenly of ischaemic heart disease (IHD) and from 8 patients who had died suddenly of other causes. Mean FPA concentration in the IHD group was five times higher than that in the non-IHD group. This difference was almost entirely due to the high FPA level in the IHD subjects with a history of the disease. The FPA difference between the IHD and non-IHD groups is unlikely to have been due to differences in methods of resuscitation. A possible interpretation of the findings is that thrombin production causes or aggravates the course of events leading to sudden IHD death, particularly in subjects with a past history of IHD.
通过直接心脏穿刺采集了31例因缺血性心脏病（IHD）猝死的患者以及8例因其他原因猝死的患者的血液，测定了其中纤维蛋白肽A（FPA）的浓度。IHD组的平均FPA浓度是非IHD组的五倍。这种差异几乎完全归因于有该疾病病史的IHD受试者中FPA水平较高。IHD组和非IHD组之间的FPA差异不太可能是由于复苏方法的不同。这些发现的一种可能解释是，凝血酶的产生导致或加剧了导致IHD猝死的事件进程，特别是在有IHD既往史的受试者中。
