Hashimoto N, Handa H, Nagata I, Hazama F
Neurol Res. 1984 Mar-Jun;6(1-2):33-40. doi: 10.1080/01616412.1984.11739661.
Saccular cerebral aneurysms are induced in rats treated with ligation of one or both of the common carotid arteries, experimental hypertension, and beta-aminopropionitrile feeding. Combination of ligation of the carotid artery and experimental hypertension is the minimal requirement for inducing aneurysms within a few months. beta-aminopropionitrile makes the arterial wall fragile, increasing the incidence of aneurysmal development. Induced aneurysms are strongly related to haemodynamic stresses. They are located on the large arteries at the base of the brain. Some of them apparently originate from the apex of bifurcation. The macroscopic and microscopic findings are generally in accordance with those of spontaneous lesions in man. The results of electron microscope and histochemical studies indicate the participation of leukocytes and their lysosomal enzymes in the development and growth of aneurysms. Adventitial cells are also suggested to be responsible for the growth of aneurysms.
通过结扎一侧或双侧颈总动脉、实验性高血压以及喂食β-氨基丙腈来诱导大鼠发生囊状脑动脉瘤。颈动脉结扎与实验性高血压相结合是在几个月内诱导动脉瘤形成的最低要求。β-氨基丙腈会使动脉壁变脆弱，增加动脉瘤形成的发生率。诱导形成的动脉瘤与血流动力学应力密切相关。它们位于脑底部的大动脉上。其中一些显然起源于分叉处的顶端。大体和微观发现通常与人类自发性病变的发现一致。电子显微镜和组织化学研究结果表明白细胞及其溶酶体酶参与了动脉瘤的发生和生长。外膜细胞也被认为与动脉瘤的生长有关。
