Ritter M A, Gioe T J, Sieber J M
Acta Orthop Scand. 1984 Aug;55(4):411-3. doi: 10.3109/17453678408992385.
This study dealt with the effects of polymethylmethacrylate (PMMA) in total hip and knee arthroplasty patients on serum gamma-glutamyltranspeptidase GGTP levels. Patients undergoing open reduction and internal fixation of hip fractures served as control patients. Results of this study showed that 11 of 90 total hip patients and seven of 23 total knee patients had abnormally elevated GGTP levels at 5 and 10 days postoperatively. Abnormal elevations of GGTP levels in 40 hip fracture patients, however, were not noted. Clinical findings in this study included the observations that three of the 11 hip patients with elevated GGTP levels concurrently had symptoms of anorexia, nausea and/or vomiting, along with spiking temperatures in the postoperative period. These symptoms generally occurred by 5 days following surgery and resolved uneventfully by 10 days postoperatively. Likewise, two of the seven knee patients with elevated GGTP levels in the postoperative period had the symptoms described above. No symptoms were reported from the hip fracture patients.
本研究探讨了聚甲基丙烯酸甲酯（PMMA）在全髋关节和膝关节置换患者中对血清γ-谷氨酰转肽酶（GGTP）水平的影响。接受髋关节骨折切开复位内固定术的患者作为对照。本研究结果显示，90例全髋关节置换患者中有11例、23例全膝关节置换患者中有7例在术后5天和10天时GGTP水平异常升高。然而，40例髋部骨折患者未发现GGTP水平异常升高。本研究的临床发现包括，11例GGTP水平升高的髋关节置换患者中有3例在术后同时出现厌食、恶心和/或呕吐症状，以及体温骤升。这些症状通常在术后5天出现，并在术后10天顺利缓解。同样，7例术后GGTP水平升高的膝关节置换患者中有2例出现上述症状。髋部骨折患者未报告任何症状。
