Köhler C, Eriksson L G
Anat Embryol (Berl). 1984;170(1):1-10. doi: 10.1007/BF00319452.
Antibodies to the neuropeptides somatostatin (SOM) and neurotensin were used to study the distribution of the two peptides within the septum of the rat brain. In colchicine treated rats, numerous somatostatin-positive cell bodies were found in the dorsal and ventral subdivisions of the lateral septum, along the border of the nucleus accumbens, in the ventral tip of the horizontal limb of the diagonal band of Broca as well as in the anterior hippocampal rudiment, infralimbic area and several other structures of the basal forebrain (e.g., nucleus accumbens, olfactory tubercle and substantia innominata). Cell bodies containing immunoreactivity for neurotensin were situated in the intermediate and ventral subdivisions of the lateral septum, the medial septal nucleus, the diagonal band of Broca, the rostro-medial continuation of the substantia innominata and the olfactory tubercle. In untreated rats, somatostatin positive processes formed terminal plexuses in the medial septal nucleus and along an area close to the ventricular wall of the lateral septal nucleus. Other septal nuclei, such as the diagonal band of Broca contained a sparse innervation by somatostatin positive fibers. In contrast, the nucleus accumbens, olfactory tubercle, and the substantia innominata contained a rich innervation by somatostatin positive axons and terminals. Within these structures the density of SOM positive processes show great variations with patches of densely packed terminals separated by areas of sparser or no innervation. The neurotensin positive terminals were situated predominantly within the intermediate part of the lateral septum and the medial septal nucleus. Both of these regions contained numerous pericellular baskets of neurotensin positive terminals around septal neurons. In addition to the septal innervation, several of the basal forebrain structures were rich in neurotensin positive processes with the densest innervation found in the nucleus accumbens and substantia innominata. Like the SOM-immunoreactivity distinct islands of dense neurotensin innervation separated by less or no innervation occur throughout the basal forebrain. Taken together, these findings suggest that somatostatin and neurotensin occur in separate neuronal populations and that each may influence important physiological functions within the individual septal nuclei.
利用针对神经肽生长抑素（SOM）和神经降压素的抗体，研究这两种肽在大鼠脑隔区的分布情况。在秋水仙碱处理的大鼠中，在外侧隔区的背侧和腹侧亚区、伏隔核边界、布罗卡斜带水平支腹侧尖端以及前海马原基、边缘下区和基底前脑的其他几个结构（如伏隔核、嗅结节和无名质）中发现了大量生长抑素阳性细胞体。含有神经降压素免疫反应性的细胞体位于外侧隔区的中间和腹侧亚区、内侧隔核、布罗卡斜带、无名质的 rostro - 内侧延续部分和嗅结节。在未处理的大鼠中，生长抑素阳性突起在内侧隔核以及靠近外侧隔核室壁的区域形成终末丛。其他隔核，如布罗卡斜带，生长抑素阳性纤维的神经支配稀疏。相比之下，伏隔核、嗅结节和无名质有丰富的生长抑素阳性轴突和终末神经支配。在这些结构中，SOM 阳性突起的密度变化很大，密集的终末斑块被稀疏或无神经支配的区域隔开。神经降压素阳性终末主要位于外侧隔区中间部分和内侧隔核内。这两个区域在隔区神经元周围都有大量神经降压素阳性终末的细胞周篮状结构。除了隔区神经支配外，基底前脑的几个结构富含神经降压素阳性突起，其中伏隔核和无名质的神经支配最密集。与 SOM 免疫反应性一样，整个基底前脑存在由较少或无神经支配分隔的密集神经降压素支配的不同岛状区域。综上所述，这些发现表明生长抑素和神经降压素存在于不同的神经元群体中，并且它们各自可能影响各个隔核内的重要生理功能。
