某些抑制性药物对小龙虾神经肌肉接头处谷氨酸突触反应的影响。
Effects of some depressant drugs on synaptic responses to glutamate at the crayfish neuromuscular junction.
作者信息
Wachtel R E
出版信息
Br J Pharmacol. 1984 Oct;83(2):387-91. doi: 10.1111/j.1476-5381.1984.tb16498.x.
Abstract
Excitatory junction currents produced by glutamate were recorded with an extracellular electrode at the neuromuscular junction of the crayfish. Pentobarbitone, phenobarbitone, diazepam, chlordiazepoxide and procaine had only minimal effects on current decay at concentrations which are highly effective in other preparations. The glutamate synapse in the crayfish appears relatively resistant to these drugs. In contrast, ether and halothane increased the rate of decay of the currents at concentrations which are comparable to those occurring during anaesthesia.
摘要
在小龙虾的神经肌肉接头处，用细胞外电极记录谷氨酸产生的兴奋性接头电流。戊巴比妥、苯巴比妥、地西泮、氯氮卓和普鲁卡因在对其他制剂非常有效的浓度下，对电流衰减只有极小的影响。小龙虾中的谷氨酸突触似乎对这些药物相对耐药。相比之下，乙醚和氟烷在与麻醉期间相当的浓度下增加了电流的衰减速率。
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