Torda T A, Gage P W
Br J Anaesth. 1977 Aug;49(8):771-6. doi: 10.1093/bja/49.8.771.
The effects of sodium thiopentone 19-757 mumol/litre, sodium pentobarbitone 25-806 mumol/litre, propanidid 74-1186 mumol/litre, Althesin 55-220 mumol/litre, diazepam 17.6-140 mumol/litre and ketamine 1.8-116.8 mumol/litre on the time-course of miniature end-plate currents of the excised mouse diaphragm were investigated. The currents were detected by means of extracellular electrodes and recorded with a transient recorder. The drugs had no significant effect on the growth phase of the current, but all six shortened the time-constant of the decay phase. This reduction in the duration of end-plate currents reduced the amplitude of postsynaptic potentials. A similar effect at central synapses may account for a failure of synaptic transmission caused by anaesthetic drugs and it is suggested that a reduction in the lifetime of open postsynaptic ionic channels is a common action of anaesthetic drugs.
研究了硫喷妥钠19 - 757微摩尔/升、戊巴比妥钠25 - 806微摩尔/升、丙泮尼地74 - 1186微摩尔/升、阿耳法沙龙55 - 220微摩尔/升、地西泮17.6 - 140微摩尔/升和氯胺酮1.8 - 116.8微摩尔/升对切除的小鼠膈膜微小终板电流时程的影响。电流通过细胞外电极检测，并用瞬态记录仪记录。这些药物对电流的增长阶段没有显著影响，但所有六种药物都缩短了衰减阶段的时间常数。终板电流持续时间的这种缩短降低了突触后电位的幅度。在中枢突触处的类似效应可能解释了麻醉药物引起的突触传递失败，并且有人提出开放的突触后离子通道寿命的缩短是麻醉药物的共同作用。
