对细胞毒性药物有抗性的细胞可被单克隆抗体识别。
Cells resistant to cytotoxic drugs are recognized by monoclonal antibody.
作者信息
O'Hara C J, Grover J, Price G B
出版信息
J Clin Immunol. 1984 Sep;4(5):403-11. doi: 10.1007/BF00917144.
PMID:6149230
Abstract
A monoclonal antibody produced by hybridomas obtained from a mouse immunized with drug-resistant cells recognizes certain hamster and human drug-resistant cell lines but not their drug-sensitive parental lines. Preliminary characterization of the antigen indicates that it is a molecule of approximately 180,000 daltons. This molecule may be the P-glycoprotein previously associated with a drug-resistance permeability barrier (Riordan JR, Ling V: J Biol Chem 254:12701-12705, 1979).
摘要
用耐药细胞免疫小鼠后获得的杂交瘤所产生的一种单克隆抗体，能识别某些仓鼠和人类的耐药细胞系，但不能识别其药物敏感的亲本细胞系。对抗原的初步特性分析表明，它是一种分子量约为180,000道尔顿的分子。这种分子可能是先前与耐药性通透屏障相关的P-糖蛋白（里奥丹JR，凌V：《生物化学杂志》254:12701 - 12705，1979）。
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