Gönczöl E, Plotkin S A
J Gen Virol. 1984 Oct;65 ( Pt 10):1833-7. doi: 10.1099/0022-1317-65-10-1833.
Culture supernatants of permissive and non-permissive cells infected with human cytomegalovirus (HCMV) contain a growth factor that enhances the DNA synthesis and mitotic activity of target cells. This cytomegalovirus growth factor CMV-GF) is a heat-stable, acid-labile polypeptide that is sensitive to trypsin and dithiothreitol. CMV-GF is an early product of the infected cells and defective virions are primarily responsible for its induction. Microtubule depolymerization is necessary for the induction of DNA synthesis by the CMV-GF, since taxol, an inhibitor of microtubule depolymerization, blocks its effect.
感染人巨细胞病毒（HCMV）的允许细胞和非允许细胞的培养上清液中含有一种生长因子，该生长因子可增强靶细胞的DNA合成和有丝分裂活性。这种巨细胞病毒生长因子（CMV-GF）是一种热稳定、酸不稳定的多肽，对胰蛋白酶和二硫苏糖醇敏感。CMV-GF是受感染细胞的早期产物，缺陷病毒粒子是其诱导产生的主要原因。微管解聚是CMV-GF诱导DNA合成所必需的，因为微管解聚抑制剂紫杉醇会阻断其作用。
