Confirmation of F13A assignment and sequence information concerning F13A-HLA-GLO.

The polymorphism of the blood clotting factor F13A was examined in some of our Danish material of normal families. A total of four alleles were recognized, with allele frequencies as follows: F13A *1 = 0.817, F13A *2 = 0.177, F13A *4 = 0.003 and a new allele F13A *5 = 0.003. The distribution of unrelated individuals did not deviate significantly from the Hardy-Weinberg expectation. Linkage of F13A with HLA was confirmed (z = 5.18, theta = 0.17 in males and z = 0.14, theta = 0.37 in females). The sequence of the three systems F13A, HLA and GLO was found to be F13A-HLA-GLO as judged from two families each with a recombinant within the HLA system in males.