Rosman J B, ter Wee P M, Piers-Becht G P, Sluiter W J, van der Woude F J, Meijer S, Donker A J
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:567-73.
We performed a prospective randomised trial in 199 patients with various stages of renal failure. Stratified for sex, age and renal insufficiency, 105 patients were assigned to a protein (Pr)-restricted group (0.4-0.6g/kg/BW), and 94 to a control group. Pr-restriction led to a significant reduction in the excretion of urea, phosphate and protein. Survival of renal function was significantly better in Pr-restricted patients. Median serum creatinine concentration increased in the control group (p less than 0.05), but remained stable in Pr-restricted patients. We conclude that Pr-restriction retards, or even halts the progression of chronic renal failure.
我们对199例处于不同肾衰竭阶段的患者进行了一项前瞻性随机试验。根据性别、年龄和肾功能不全情况进行分层，105例患者被分配至蛋白质（Pr）限制组（0.4 - 0.6g/kg体重），94例患者被分配至对照组。Pr限制导致尿素、磷酸盐和蛋白质排泄显著减少。Pr限制组患者的肾功能存活情况明显更好。对照组患者的血清肌酐浓度中位数升高（p小于0.05），但Pr限制组患者的血清肌酐浓度保持稳定。我们得出结论，Pr限制可延缓甚至阻止慢性肾衰竭的进展。
