慢性肾衰竭中的蛋白质限制
Protein restriction in chronic renal failure.
作者信息
Kist-van Holthe tot Echten J E, Nauta J, Hop W C, de Jong M C, Reitsma-Bierens W C, Ploos van Amstel S L, van Acker K J, Noordzij C M, Wolff E D
机构信息
Department of Paediatrics, Sophia Children's Hospital/University Hospital Rotterdam, The Netherlands.
出版信息
Arch Dis Child. 1993 Mar;68(3):371-5. doi: 10.1136/adc.68.3.371.
The aim of the study was to investigate the effect of a protein restricted diet on renal function and growth of children with chronic renal failure. In a multicentre prospective study 56 children (aged 2-18 years) with chronic renal failure were randomly assigned to the protein restricted (0.8-1.1 g/kg/day) or the control group. All children were followed up by the same paediatrician and dietitian. After a follow up period of three years there was no significant difference in glomerular filtration rate between children on a protein restricted diet and children of the control group. There was no significant difference in weight with respect to height and height SD score between the protein restricted and the control group. Compliance with the protein restricted diet, as indicated by the prospective diet diaries and the serum urea:creatinine ratio, was good. This study shows that children with chronic renal failure do not benefit from a protein restricted diet.
该研究的目的是调查蛋白质限制饮食对慢性肾衰竭儿童肾功能和生长发育的影响。在一项多中心前瞻性研究中，56名年龄在2至18岁的慢性肾衰竭儿童被随机分配到蛋白质限制组（0.8 - 1.1克/千克/天）或对照组。所有儿童均由同一位儿科医生和营养师进行随访。经过三年的随访期，蛋白质限制饮食组儿童与对照组儿童的肾小球滤过率没有显著差异。蛋白质限制组与对照组在身高体重比和身高标准差评分方面没有显著差异。根据前瞻性饮食日记和血清尿素：肌酐比值显示，对蛋白质限制饮食的依从性良好。这项研究表明，慢性肾衰竭儿童无法从蛋白质限制饮食中获益。
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