蛋黄磷脂对以乳剂形式给予大鼠的辅酶Q10的血浆清除及组织分布的影响。
Effect of egg yolk phospholipids plasma elimination and tissue distribution of coenzyme Q10 administered in an emulsion to rats.
作者信息
Yamaguchi H, Watanabe K, Hayashi M, Awazu S
出版信息
J Pharm Pharmacol. 1984 Nov;36(11):766-7. doi: 10.1111/j.2042-7158.1984.tb04869.x.
Abstract
When coenzyme Q10 (CoQ10) in fat emulsion emulsified with egg yolk phospholipids (PL) was administered intravenously to rats, CoQ10 was eliminated more rapidly than when it was solubilized with a polyoxyethylene derivative of hydrogenated castor oil. Although CoQ10 in emulsion form is distributed mainly to liver, increase of PL concentration in the emulsion increased the distribution of CoQ10 to heart which is a target organ for CoQ10.
摘要
当用蛋黄磷脂（PL）乳化的脂肪乳剂中的辅酶Q10（CoQ10）静脉注射给大鼠时，CoQ10的消除速度比用氢化蓖麻油的聚氧乙烯衍生物增溶时更快。尽管乳剂形式的CoQ10主要分布到肝脏，但乳剂中PL浓度的增加会增加CoQ10向心脏的分布，而心脏是CoQ10的靶器官。
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