Scalori V, Alessandrì M G, Mian M, Giovannini L, Bertelli A A
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
Int J Tissue React. 1988;10(2):95-7.
Coenzyme Q10 (CoQ10) kinetics was investigated in rat tissues after oral treatment. CoQ10 passes quickly from plasma into the tissue examined, reaching levels higher than physiological ones; the liver shows the maximal CoQ10 concentrations. Our results indicate that oral treatment makes it possible to obtain good tissue levels of CoQ10 that might be of clinical value against endogenous CoQ10 insufficiencies due either to pathological alterations and/or to drug administration.
口服给药后，对大鼠组织中的辅酶Q10（CoQ10）动力学进行了研究。CoQ10从血浆迅速进入所检测的组织，其水平高于生理水平；肝脏中CoQ10浓度最高。我们的结果表明，口服给药能够使组织中CoQ10达到良好水平，这对于因病理改变和/或药物给药导致的内源性CoQ10不足可能具有临床价值。
