Verrillo A, de Teresa A, Rucco E
Boll Soc Ital Biol Sper. 1984 Dec 30;60(12):2261-6.
The day-time variations of blood sugar and associated changes in plasma insulin and somatostatin levels in response to glucose-glucagon load were investigated in eight healthy volunteers. The glucose-glucagon test was performed in the same subjects at 9.00 a.m., at 5.00 p.m. and at midnight after 10 hrs of fasting. The blood sugar values were higher in the midnight while the corresponding plasma insulin levels were significantly lower. Plasma somatostatin levels did not differ at the different times of the day. These results suggest that the circadian variations of the glucose tolerance are correlated to a simultaneous circadian rhythmicity in the insulin response in the sense of a decreased insulin release later in the day. Somatostatin does not seem involved in the circadian variation of beta cell responsiveness observed in healthy volunteers.
对8名健康志愿者进行了研究，以探讨血糖的日间变化以及血浆胰岛素和生长抑素水平对葡萄糖-胰高血糖素负荷的相关变化。在上午9点、下午5点和禁食10小时后的午夜，对同一批受试者进行葡萄糖-胰高血糖素测试。午夜时血糖值较高，而相应的血浆胰岛素水平显著较低。一天中不同时间的血浆生长抑素水平没有差异。这些结果表明，糖耐量的昼夜变化与胰岛素反应中同时存在的昼夜节律相关，即一天中较晚时候胰岛素释放减少。生长抑素似乎不参与健康志愿者中观察到的β细胞反应性的昼夜变化。
