Hintz R L, Liu F, Marshall L B, Chang D
J Clin Endocrinol Metab. 1980 Feb;50(2):405-7. doi: 10.1210/jcem-50-2-405.
Insulin-like growth factor-I is a human plasma peptide with strong structural homology to human prosinsulin. This peptide has been classified as a somatomedin on the basis of its biological actions and growth hormone dependence. We have generated an antibody to the synthetic 12 amino acid C-peptide region of insulin-like growth factor-I and used it to compare three somatomedin preparations to insulin-like growth factor-I. We also compared these somatomedin preparations to insulin-like growth factor-I using the standard SM-C RIA. We conclude that insulin-like growth factor-I and somatomedin-C behave identically in these two RIA's and are very similar if not identical molecules.
胰岛素样生长因子-I是一种人血浆肽，与人类胰岛素原具有很强的结构同源性。基于其生物学作用和对生长激素的依赖性，该肽被归类为生长调节素。我们制备了一种针对胰岛素样生长因子-I合成的12个氨基酸C肽区域的抗体，并用它将三种生长调节素制剂与胰岛素样生长因子-I进行比较。我们还使用标准的SM-C RIA将这些生长调节素制剂与胰岛素样生长因子-I进行比较。我们得出结论，胰岛素样生长因子-I和生长调节素-C在这两种放射免疫分析中表现相同，并且如果不是完全相同的分子，也是非常相似的分子。
