Chui H C, Damasio A R
J Neurol. 1980 Jan;222(3):145-57. doi: 10.1007/BF00313113.
Sixty cases of distinctive progressive and fatal encephalopathy have been reported in patients undergoing long-term hemodialysis. An analysis of their records reveals that mean duration of hemodialysis prior to onset is 2.5 years, while mean duration of clinical course until death is 6.3 months. The most frequent clinical manifestations include disturbances in communication (87%), cognition (66%) and movement (93%). Nonspecific electroencephalographic abnormalities are present in all cases. The condition is possibly related to some yet unidentified metabolic disorder. There is no effective therapy.
据报道，60例接受长期血液透析的患者出现了一种特殊的进行性致命性脑病。对他们的病历分析显示，发病前血液透析的平均时长为2.5年，而直至死亡的临床病程平均时长为6.3个月。最常见的临床表现包括交流障碍（87%）、认知障碍（66%）和运动障碍（93%）。所有病例均存在非特异性脑电图异常。该病症可能与某种尚未明确的代谢紊乱有关。目前尚无有效治疗方法。
