Olofsson S, Khanna B, Lycke E
J Gen Virol. 1980 Mar;47(1):1-9. doi: 10.1099/0022-1317-47-1-1.
Microsomal sialyl transferase and galactosyl transferase activities of herpes simplex virus-infected GMK and BHK cells were studied. Apparent Km values calculated for sialyl and galactosyl transferases differed significantly from the corresponding values of uninfected cells. Both transferases of HSV-infected cells demonstrated acceptor specificities different from those of uninfected cells. It is suggested that herpes simplex virus might influence glycosylation of proteins by modifying the glycosyl transferases of the infected cells.
研究了单纯疱疹病毒感染的GMK和BHK细胞的微粒体唾液酸转移酶和半乳糖基转移酶活性。计算得出的唾液酸转移酶和半乳糖基转移酶的表观Km值与未感染细胞的相应值有显著差异。单纯疱疹病毒感染细胞的两种转移酶表现出与未感染细胞不同的受体特异性。提示单纯疱疹病毒可能通过改变被感染细胞的糖基转移酶来影响蛋白质的糖基化。
