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一种稳定的前列环素类似物预防小鼠脑型疟疾

Prevention of murine cerebral malaria by a stable prostacyclin analog.

作者信息

Sliwa K, Grundmann H J, Neifer S, Chaves M F, Sahlmüller G, Blitstein-Willinger E, Bienzle U, Kremsner P G

机构信息

Landesinstitut für Tropenmedizin Berlin, Germany.

出版信息

Infect Immun. 1991 Oct;59(10):3846-8. doi: 10.1128/iai.59.10.3846-3848.1991.

DOI:10.1128/iai.59.10.3846-3848.1991
PMID:1716616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258963/
Abstract

Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.

摘要

伊洛前列素，一种合成的前列环素类似物，成功地预防了小鼠脑型疟疾的发展。在体外和体内，伊洛前列素均可抑制疟原虫抗原诱导的肿瘤坏死因子（TNF）产生。对TNF mRNA的Northern分析显示，疟原虫抗原诱导的TNF表达在转录水平受到抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b82/258963/dd4560f0e5be/iai00046-0515-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b82/258963/dd4560f0e5be/iai00046-0515-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b82/258963/dd4560f0e5be/iai00046-0515-a.jpg

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1
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本文引用的文献

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Fibrinolytic activity of 6-keto-prostaglandin E1.6-酮-前列腺素E1的纤溶活性
Thromb Haemost. 1983 Dec 30;50(4):893.
2
Effects of PGI2 and PGI analogues on cAMP levels in cultured endothelial and smooth muscle cells derived from bovine arteries.前列环素（PGI2）及其类似物对源自牛动脉的培养内皮细胞和平滑肌细胞中环磷酸腺苷（cAMP）水平的影响。
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Prostacyclin in Falciparum malaria.恶性疟中的前列环素
Malaria antigen and cytokine-induced production of reactive nitrogen intermediates by murine macrophages: no relevance to the development of experimental cerebral malaria.
疟疾抗原和细胞因子诱导小鼠巨噬细胞产生反应性氮中间体：与实验性脑型疟疾的发展无关。
Immunology. 1993 Feb;78(2):286-90.
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Specificity of in vivo tumor rejection assessed by mixing immune spleen cells with target and unrelated tumor cells.通过将免疫脾细胞与靶肿瘤细胞及无关肿瘤细胞混合来评估体内肿瘤排斥反应的特异性。
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Monokines and lymphokines in malarial pathology.疟疾病理学中的单核因子和淋巴因子。
Ann Trop Med Parasitol. 1987 Oct;81(5):577-85. doi: 10.1080/00034983.1987.11812159.
6
Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria.肿瘤坏死因子（恶病质素）作为鼠脑型疟疾的关键介质。
Science. 1987 Sep 4;237(4819):1210-2. doi: 10.1126/science.3306918.
7
Malarial parasites induce TNF production by macrophages.疟原虫可诱导巨噬细胞产生肿瘤坏死因子。
Immunology. 1988 Jun;64(2):227-31.
8
Roles of tumour necrosis factor in the illness and pathology of malaria.肿瘤坏死因子在疟疾发病及病理过程中的作用。
Trans R Soc Trop Med Hyg. 1989 Jul-Aug;83(4):436-40. doi: 10.1016/0035-9203(89)90240-x.
9
Tumor-necrosis factor and other cytokines in cerebral malaria: experimental and clinical data.脑型疟疾中的肿瘤坏死因子及其他细胞因子：实验与临床数据
Immunol Rev. 1989 Dec;112:49-70. doi: 10.1111/j.1600-065x.1989.tb00552.x.
10
Monoclonal antibody against interferon gamma can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor.抗γ干扰素单克隆抗体可预防实验性脑型疟疾及其相关的肿瘤坏死因子过度产生。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5572-4. doi: 10.1073/pnas.86.14.5572.