Prevention of murine cerebral malaria by a stable prostacyclin analog.
作者信息
Sliwa K, Grundmann H J, Neifer S, Chaves M F, Sahlmüller G, Blitstein-Willinger E, Bienzle U, Kremsner P G
机构信息
Landesinstitut für Tropenmedizin Berlin, Germany.
出版信息
Infect Immun. 1991 Oct;59(10):3846-8. doi: 10.1128/iai.59.10.3846-3848.1991.
Abstract
Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.
摘要
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