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4,5',8-三甲基补骨脂素经近紫外光激活后对小鼠细胞中干扰素产生及抗病毒作用的抑制。简报

Inhibition of interferon production and antiviral action in mouse cells by 4,5',8-trimethylpsoralen activated with near ultraviolet light. Brief report.

作者信息

Sakaguchi A Y, Stevenson D, Gordon I

出版信息

Arch Virol. 1980;63(1):69-74. doi: 10.1007/BF01320762.

DOI:10.1007/BF01320762
PMID:6154450
Abstract

The DNA of mammalian cells treated with 4,5',8-trimethylpsoralen (Trioxsalen) is crosslinked (preventing transcription) only after photoactivation with near ultraviolet light. Suppression of gene action in cocultivated or fused cultures, including both induction and antiviral action of fibroblast interferon, can consequently be limited to pretreated cells, an advantage over actinomycin treatment.

摘要

用4,5',8-三甲基补骨脂素（三甲沙林）处理的哺乳动物细胞的DNA仅在近紫外光光激活后才会发生交联（阻止转录）。因此，在共培养或融合培养物中基因作用的抑制，包括成纤维细胞干扰素的诱导作用和抗病毒作用，可能仅限于预处理的细胞，这是优于放线菌素处理的一个优点。

相似文献

1
Inhibition of interferon production and antiviral action in mouse cells by 4,5',8-trimethylpsoralen activated with near ultraviolet light. Brief report.4,5',8-三甲基补骨脂素经近紫外光激活后对小鼠细胞中干扰素产生及抗病毒作用的抑制。简报
Arch Virol. 1980;63(1):69-74. doi: 10.1007/BF01320762.
2
Differential inhibition of cellular RNAs by photosensitized trioxalen.光致敏三甲沙林对细胞RNA的差异性抑制作用
Nucleic Acids Res. 1983 Sep 24;11(18):6453-64. doi: 10.1093/nar/11.18.6453.
3
High levels of 4,5',8-trimethylpsoralen photoinduced furan-side monoadducts can block cross-link removal in normal human cells.
Photochem Photobiol. 1988 Mar;47(3):321-6. doi: 10.1111/j.1751-1097.1988.tb02733.x.
4
Inhibition by trioxalen (psoralen) plus near-ultraviolet light of the induction of ornithine decarboxylase in Chinese-hamster cells.三甲沙林（补骨脂素）加近紫外线对中国仓鼠细胞中鸟氨酸脱羧酶诱导的抑制作用。
Biochem J. 1979 Oct 1;183(1):179-80. doi: 10.1042/bj1830179.
5
Photosensitized inhibition of nitrate reductase induction by 4,5',8-trimethylpsoralen and near ultraviolet light.
Biochim Biophys Acta. 1978 Jul 24;519(2):499-506. doi: 10.1016/0005-2787(78)90102-8.
6
Interstrand crosslinks due to 4,5',8-trimethylpsoralen and near ultraviolet light in specific sequences of animal DNA. Effect of constitutive chromatin structure and of induced transcription.4,5',8-三甲基补骨脂素与近紫外光诱导动物DNA特定序列形成链间交联。组成型染色质结构及诱导转录的影响。
J Mol Biol. 1988 May 20;201(2):339-51. doi: 10.1016/0022-2836(88)90142-8.
7
Evidence for contamination of origin DNA isolated after an in vivo treatment of mammalian cells with 4,5',8-trimethylpsoralen.
Biochim Biophys Acta. 1986 Aug 22;867(4):187-94. doi: 10.1016/0167-4781(86)90033-3.
8
Interstrand crosslinks in DNA of phage lambda after exposure to 8-methoxypsoralen and trimethylpsoralen in the presence of light.在光照条件下，噬菌体λ的DNA在暴露于8-甲氧基补骨脂素和三甲基补骨脂素后形成的链间交联。
J Invest Dermatol. 1979 Sep;73(3):236-8. doi: 10.1111/1523-1747.ep12514302.
9
Dark and photoreactivity of 4'-aminomethyl-4,5',8-trimethylpsoralen with T7 phage.4'-氨甲基-4,5',8-三甲基补骨脂素与T7噬菌体的暗反应和光反应活性
J Photochem Photobiol B. 1990 Apr 15;5(2):167-78. doi: 10.1016/1011-1344(90)80004-h.
10
Cell cycle analysis of cultured mammalian cells after exposure to 4,5',8-trimethylpsoralen and long-wave ultraviolet light.暴露于4,5',8-三甲基补骨脂素和长波紫外线后培养的哺乳动物细胞的细胞周期分析。
J Invest Dermatol. 1981 May;76(5):409-13. doi: 10.1111/1523-1747.ep12520956.

本文引用的文献

1
INHIBITION OF INTERFERON ACTION BY P-FLUOROPHENYLALANINE.
Nature. 1964 Jul 25;203:366-7. doi: 10.1038/203366a0.
2
Skin-photosensitizing furocoumarins: photochemical interaction between DNA and -O14CH3 bergapten (5-methoxy-psoralen).皮肤光敏性呋喃香豆素：DNA与-O14CH3补骨脂素（5-甲氧基补骨脂素）之间的光化学相互作用。
Photochem Photobiol. 1966 Sep;5(9):739-45. doi: 10.1111/j.1751-1097.1966.tb05823.x.
3
Cell killing by actinomycin D in relation to the growth cycle of chinese hamster cells.放线菌素D对中国仓鼠细胞生长周期的细胞杀伤作用。
J Cell Biol. 1969 Aug;42(2):366-77. doi: 10.1083/jcb.42.2.366.
4
Membrane potentials of human fibroblast strains in culture.培养中的人成纤维细胞株的膜电位。
J Cell Physiol. 1968 Feb;71(1):61-3. doi: 10.1002/jcp.1040710108.
5
Photosensitization of skin in vivo by furocoumarins (psoralens).补骨脂素（呋喃香豆素）对皮肤的体内光敏作用。
Biochim Biophys Acta. 1969 Nov 19;195(1):197-206. doi: 10.1016/0005-2787(69)90616-9.
6
Psoralen monoadducts and interstrand cross-links in DNA.补骨脂素在DNA中的单加合物和链间交联。
Biochim Biophys Acta. 1971 Nov 29;254(1):30-9. doi: 10.1016/0005-2787(71)90111-0.
7
Inhibition of nucleic acids synthesis in Ehrlich ascites tumor cells by irradiation in vitro in the presence of skin-photosensitizing furocoumarins.在皮肤光敏性呋喃香豆素存在的情况下，体外照射对艾氏腹水瘤细胞核酸合成的抑制作用。
Experientia. 1972 Feb 15;28(2):148. doi: 10.1007/BF01935721.
8
Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.在呋喃香豆素（补骨脂素）存在的情况下，光诱导DNA交联。用λ噬菌体、大肠杆菌和小鼠白血病细胞进行的研究。
Biochim Biophys Acta. 1970 Sep 17;217(1):30-9. doi: 10.1016/0005-2787(70)90119-x.
9
A method for the large scale production of potent interferon preparations.一种大规模生产高效干扰素制剂的方法。
Proc Soc Exp Biol Med. 1974 Jul;146(3):809-15. doi: 10.3181/00379727-146-38196.
10
The membrane potentials of fibroblasts in different environments.不同环境中成纤维细胞的膜电位。
J Cell Physiol. 1974 Aug;84(1):141-5. doi: 10.1002/jcp.1040840116.