Buamah P K, Evans L, Ward A M
Clin Chim Acta. 1980 Mar 28;102(2-3):147-51. doi: 10.1016/0009-8981(80)90027-3.
Acetylcholinesterase isoenzyme patterns were determined in amniotic fluid from 140 normal pregnancies and from 68 pregnancies with various fetal abnormalities. A fast acetylcholinesterase isoenzyme was detected in all cases of neural tube defect, exomphalos and intrauterine death. The fast isoenzyme was not seen in any of the normal pregnancies. Blood-contaminated amniotic fluids with false positive elevation of alphafetoprotein gave a single isoenzyme band. The qualitative demonstration of a fast acetylcholinesterase isoenzyme in amniotic fluid provides a useful adjunct to the alphafetoprotein assay in the prenatal diagnosis of neural tube defects.
测定了140例正常妊娠和68例有各种胎儿异常妊娠的羊水乙酰胆碱酯酶同工酶谱。在所有神经管缺陷、脐膨出和宫内死亡病例中均检测到一种快速乙酰胆碱酯酶同工酶。在任何正常妊娠中均未见到这种快速同工酶。甲胎蛋白假阳性升高的受血液污染的羊水呈现单一同工酶带。羊水快速乙酰胆碱酯酶同工酶的定性检测为神经管缺陷的产前诊断中甲胎蛋白测定提供了一种有用的辅助手段。
